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Article

A Generally Applicable Translational Strategy Identifies S100A4 as a Candidate Gene in Allergy

8 Jan 2014

Abstract excerpt

The identification of diagnostic markers and therapeutic candidate genes in common diseases is complicated by the involvement of thousands of genes. We hypothesized that genes co-regulated with a key gene in allergy, IL13, would form a module that could help to identify candidate genes. We identified a T helper 2 (TH2) cell module by small interfering RNA-mediated knockdown of 25 putative IL13-regulating...

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PMID: 24401939
DOI: 10.1126/scitranslmed.3007410

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