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Article

Identification of the third binding site of arsenic in human arsenic (III) methyltransferase.

PloS one - 1 Jan 2013

Li Xiangli, Geng Zhirong, Chang Jiayin, Wang Shuping, Song Xiaoli, Hu Xin, Wang Zhilin

Abstract excerpt

Arsenic (III) methyltransferase (AS3MT) catalyzes the process of arsenic methylation. Each arsenite (iAs(3+)) binds to three cysteine residues, methylarsenite (MMA(3+)) binds to two, and dimethylarsenite (DMA(3+)) binds to one. However, only two As-binding sites (Cys156 and Cys206) have been confirmed on human AS3MT (hAS3MT). The third As-binding site is still undefined. Residue Cys72 in Cyanidioschyzon merolae...

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Identifiers

PMID: 24391919
DOI: 10.1371/journal.pone.0084231
PMCID: PMC3877260

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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