Article
Dehydroepiandrosterone sulphate as a putative protective factor against tardive dyskinesia.
Progress in neuro-psychopharmacology & biological psychiatry - 3 Apr 2014
Ivanova Svetlana A, Geers Lisanne M, Al Hadithy Asmar F Y, Pechlivanoglou Petros, Semke Arkadiy V, Vyalova Natalia M, Rudikov Evgeniy V, Fedorenko Olga Y, Wilffert Bob, Bokhan Nikolay A, Brouwers Jacobus R B J, Loonen Anton J M
Abstract excerpt
BACKGROUND: Tardive dyskinesia (TD) is a potentially irreversible consequence of long term treatment with antipsychotic drugs which is according to a well-known theory believed to be related to oxidative stress induced neurotoxicity. Dehydroepiandrosterone (DHEA) is an endogenous antioxidant with neuroprotective activity. The biosynthesis of DHEA depends upon the activity of cytochrome P450c17α (CYP17). The gene...
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