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Article

Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease.

Neurobiology of disease - 1 Apr 2014

Davies Sian E, Hallett Penelope J, Moens Thomas, Smith Gaynor, Mangano Emily, Kim Hyoung Tae, Goldberg Alfred L, Liu Ji-Long, Isacson Ole, Tofaris George K

Abstract excerpt

Parkinson's disease is a neurodegenerative disorder, characterized by accumulation and misfolding of α-synuclein. Although the level of α-synuclein in neurons is fundamentally linked to the onset of neurodegeneration, multiple pathways have been implicated in its degradation, and it remains unclear which are the critical ubiquitination enzymes that protect against α-synuclein accumulation in vivo. The ubiquitin...

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Identifiers

PMID: 24388974
DOI: 10.1016/j.nbd.2013.12.011
PMCID: PMC3988924

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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