Substrate-dependent gene regulation of self-assembled human MSC spheroids on chitosan membranes.

doi:10.1186/1471-2164-15-10

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Article

Substrate-dependent gene regulation of self-assembled human MSC spheroids on chitosan membranes.

BMC genomics - 5 Jan 2014

Yeh Hsi-Yi, Liu Bing-Hsien, Sieber Martin, Hsu Shan-Hui

Abstract excerpt

BACKGROUND: Three-dimensional (3D) multicellular spheroids of mesenchymal stem cells (MSCs) are generally regarded to have beneficial properties over MSCs in monolayer. Recent literatures have documented that MSCs can self-assemble into 3D spheroids with a greater capacity for differentiation into various cell types when grown on chitosan (CS), a biopolymer. The genomic modulation occurring in these MSC spheroids...

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PMID: 24387160
DOI: 10.1186/1471-2164-15-10
PMCID: PMC4046657

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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