Article
STAT3 rs3816769 polymorphism correlates with gene expression level and may predispose to nonsmall cell lung cancer: a preliminary study.
Polskie Archiwum Medycyny Wewnetrznej - 1 Jan 2013
Domańska Daria, Antczak Adam, Pastuszak-Lewandoska Dorota, Górski Paweł, Kordiak Jacek, Czarnecka Karolina, Migdalska-Sęk Monika, Nawrot Ewa, Kiszałkiewcz Justyna, Brzeziańska Ewa
Abstract excerpt
INTRODUCTION: The STAT3 gene functions as both the oncogene and the regulator of immunity. Despite its important role in cancer development and regulation of the immune cells, studies of single nucleotide polymorphisms (SNPs) of the STAT3 gene and the associated risk of lung cancer are sparse. OBJECTIVES: In the present study, we evaluated the association of SNPs (rs744 166 [AG] and rs3 816 769 [CT]) with...
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