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Article

βIII-tubulin overexpression is linked to aggressive tumor features and genetic instability in urinary bladder cancer.

Human pathology - 1 Mar 2017

Hinsch Andrea, Chaker Aref, Burdelski Christian, Koop Christina, Tsourlakis Maria Christina, Steurer Stefan, Rink Michael, Eichenauer Till Simon, Wilczak Waldemar, Wittmer Corinna, Fisch Margit, Simon Ronald, Sauter Guido, Büschek Franziska, Clauditz Till, Minner Sarah, Jacobsen Frank

Abstract excerpt

Development of genetic instability is a hallmark of tumor progression. Type III β-tubulin (TUBB3) is a component of microtubules involved in chromosome segregation. Its overexpression has been linked to adverse features of urinary bladder cancer. To investigate the role of TUBB3 for development of genetic instability, we compared TUBB3 expression with histopathological features and surrogate markers of genetic...

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Source

Identifiers

PMID: 28025079
DOI: 10.1016/j.humpath.2016.11.005

Genes

TUBB3
CCND1
FGFR1
RAF1

Provenance

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