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Article

A novel heterozygous mutation (F252Y) in exon 7 of the IRF6 gene is associated with oral squamous cell carcinomas.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2013

Melath Anil, Santhakumar Gopi Krishnan, Madhavannair Shyam Sunder, Nedumgottil Binoy Mathews, Ramanathan Arvind

Abstract excerpt

BACKGROUND: Interferon regulatory factor 6 (IRF6) is a transcription factor with distinct and conserved DNA and protein binding domains. Mutations within the protein binding domain have been significantly observed in subjects with orofacial cleft relative to healthy controls. In addition, recent studies have identified loss of expression of IRF6 due to promoter hypermethylation in cutaneous squamous cell...

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Identifiers

PMID: 24377609
DOI: 10.7314/apjcp.2013.14.11.6803

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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A novel heterozygous mutation (F252Y) in exon 7 of the IRF6 gene is associated with oral squamous cell carcinomas.PMID 24377609Read ↗

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