Immunoglobulin M oligoclonal bands: biomarker of targetable inflammation in primary progressive multiple sclerosis.

doi:10.1002/ana.24190

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Article

Immunoglobulin M oligoclonal bands: biomarker of targetable inflammation in primary progressive multiple sclerosis.

Annals of neurology - 1 Aug 2014

Villar Luisa M, Casanova Bonaventura, Ouamara Nadia, Comabella Manuel, Jalili Farzaneh, Leppert David, de Andrés Clara, Izquierdo Guillermo, Arroyo Rafael, Avşar Timuçin, Lapin Sergey V, Johnson Trina, Montalbán Xavier, Fernández Oscar, Álvarez-Lafuente Roberto, Masterman Donna, García-Sánchez María I, Coret Francisco, Siva Aksel, Evdoshenko Evgeniy, Álvarez-Cermeño José C, Bar-Or Amit

Abstract excerpt

OBJECTIVE: To identify a biomarker distinguishing patients who, despite a primary progressive multiple sclerosis (PPMS) clinical course, may nonetheless benefit from immune therapy. METHODS: The presence or absence of both immunoglobulin (Ig) G and IgM oligoclonal bands (OCB) was blindly examined in paired cerebrospinal fluid (CSF) and serum samples from a large PPMS patient cohort, and related to clinical and...

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PMID: 24909126
DOI: 10.1002/ana.24190

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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