Article
ITIH3 polymorphism may confer susceptibility to psychiatric disorders by altering the expression levels of GLT8D1.
Journal of psychiatric research - 1 Mar 2014
Sasayama Daimei, Hori Hiroaki, Yamamoto Noriko, Nakamura Seiji, Teraishi Toshiya, Tatsumi Masahiko, Hattori Kotaro, Ota Miho, Higuchi Teruhiko, Kunugi Hiroshi
Abstract excerpt
A recent genome-wide analysis indicated that a polymorphism (rs2535629) of ITIH3 showed the strongest association signal with susceptibility to psychiatric disorders in Caucasian populations. The aim of the study was to replicate the association of rs2535629 with schizophrenia and major depressive disorder (MDD) in Japanese subjects. A total of 611 patients with schizophrenia, 868 with MDD, and 1193 healthy...
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