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Article

Calreticulin mutations and long-term survival in essential thrombocythemia.

Leukemia - 1 Dec 2014

Tefferi A, Wassie E A, Lasho T L, Finke C, Belachew A A, Ketterling R P, Hanson C A, Pardanani A, Gangat N, Wolanskyj A P

Abstract excerpt

The impact of calreticulin (CALR) mutations on long-term survival in essential thrombocythemia (ET) was examined in 299 patients whose diagnosis predated 2006. Mutational frequencies were 53% for Janus kinase 2 (JAK2), 32% for CALR and 3% for MPL; the remaining 12% were 'triple-negative'. We confirmed the association of mutant CALR (vs JAK2V617F) with younger age (P=0.002), male sex (P=0.01), higher platelet...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24791854
DOI: 10.1038/leu.2014.148

Genes

CALR
JAK2
MPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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