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Medaka fish exhibits longevity gender gap, a natural drop in estrogen and telomere shortening during aging: a unique model for studying sex-dependent longevity

1 Dec 2013

Abstract excerpt

INTRODUCTION: Females having a longer telomere and lifespan than males have been documented in many animals. Such linkage however has never been reported in fish. Progressive shortening of telomere length is an important aging mechanism. Mounting in vitro evidence has shown that telomere shortening beyond a critical length triggered replicative senescence or cell death. Estrogen has been postulated as a key...

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Share to Genetics, Aging, and Longevity in Model Organisms
Share to Menopause: Health Impacts and Treatments
Share to Telomeres, Telomerase, and Senescence

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PMID: 24364913
DOI: 10.1186/1742-9994-10-78

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