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Article

Short-patch single-strand break repair in ataxia oculomotor apraxia-1.

Biochemical Society transactions - 1 Jun 2009

Reynolds John J, El-Khamisy Sherif F, Caldecott Keith W

Abstract excerpt

AOA1 (ataxia oculomotor apraxia-1) results from mutations in aprataxin, a component of DNA strand break repair that removes AMP from 5'-termini. In the present article, we provide an overview of this disease and review recent experiments demonstrating that short-patch repair of oxidative single-strand breaks in AOA1 cell extracts bypasses the point of aprataxin action and stalls at the final step of DNA ligation,...

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Identifiers

PMID: 19442253
DOI: 10.1042/BST0370577

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Short-patch single-strand break repair in ataxia oculomotor apraxia-1.PMID 19442253Read ↗

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