Article
The OCT4 pseudogene POU5F1B is amplified and promotes an aggressive phenotype in gastric cancer.
Oncogene - 8 Jan 2015
Hayashi H, Arao T, Togashi Y, Kato H, Fujita Y, De Velasco M A, Kimura H, Matsumoto K, Tanaka K, Okamoto I, Ito A, Yamada Y, Nakagawa K, Nishio K
Abstract excerpt
POU5F1B (POU domain class 5 transcription factor 1B), a processed pseudogene that is highly homologous to OCT4, was recently shown to be transcribed in cancer cells, but its clinical relevance and biological function have remained unclear. We now show that POU5F1B, which is located adjacent to MYC on human chromosome 8q24, is frequently amplified in gastric cancer (GC) cell lines. POU5F1B, but not OCT4, was also...
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