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Article

Scan statistic-based analysis of exome sequencing data identifies FAN1 at 15q13.3 as a susceptibility gene for schizophrenia and autism.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jan 2014

Ionita-Laza Iuliana, Xu Bin, Makarov Vlad, Buxbaum Joseph D, Roos J Louw, Gogos Joseph A, Karayiorgou Maria

Abstract excerpt

We used a family-based cluster detection approach designed to localize significant rare disease-risk variants clusters within a region of interest to systematically search for schizophrenia (SCZ) susceptibility genes within 49 genomic loci previously implicated by de novo copy number variants. Using two independent whole-exome sequencing family datasets and a follow-up autism spectrum disorder (ASD) case/control...

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Identifiers

PMID: 24344280
DOI: 10.1073/pnas.1309475110
PMCID: PMC3890869

Genes

FAN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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