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Article

BMPR1B up-regulation via a miRNA binding site variation defines endometriosis susceptibility and CA125 levels.

PloS one - 1 Jan 2013

Chang Cherry Yin-Yi, Chen Yi, Lai Ming-Tsung, Chang Hui-Wen, Cheng Jack, Chan Carmen, Chen Chih-Mei, Lee Shan-Chih, Lin Ying-Ju, Wan Lei, Tsai Pei-Wen, Yang Su-Han, Chung Ching, Sheu Jim Jinn-Chyuan, Tsai Fuu-Jen

Abstract excerpt

BACKGROUND: Bone morphogenetic protein receptor I B (BMPR1B) is a transmembrane receptor mediating TGF-β signal transduction. Recent studies indicate a tumor suppressor role for BMPR1B in ovarian cancer. Polymorphism at BMPR1B 3'UTR within the miR-125b binding site alters its binding affinity toward the miRNA, which may result in insufficient post-transcriptional repression. METHODS: Single-nucleotide...

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Identifiers

PMID: 24339876
DOI: 10.1371/journal.pone.0080630
PMCID: PMC3855056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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