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Article

Validation of nucleolar protein 4 as a novel methylated tumor suppressor gene in head and neck cancer.

Oncology reports - 1 Feb 2014

Demokan Semra, Chuang Alice Y, Pattani Kavita M, Sidransky David, Koch Wayne, Califano Joseph A

Abstract excerpt

Methylation of CpG islands in the promoter region of genes acts as a significant mechanism of epigenetic gene silencing in head and neck cancer. In the present study, we assessed the association of epigenetic alterations of a panel of 12 genes [nucleolar protein 4 (NOL4), iroquois homeobox 1 (IRX1), SLC5A8, LRRC3B, FUSSEL18, EBF3, GBX2, HMX2, SEPT9, ALX3, SOCS3 and LHX6] with head and neck squamous cell carcinoma...

Read the complete abstract on PubMed

Topics

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Share to Carcinoma, Squamous Cell
Share to CpG Islands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Gene Expression Regulation, Neoplastic

Share to Genes, Tumor Suppressor

Share to Head and Neck Neoplasms

Share to Homeodomain Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24337411
DOI: 10.3892/or.2013.2927
PMCID: PMC3896520

Genes

IRX1
NOL4
ALX3
EBF3
GBX2
HMX2
LHX6
SOCS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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