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Article

High-risk oral leukoplakia is associated with aberrant promoter methylation of multiple genes

3 Jun 2016

Abstract excerpt

BACKGROUND: Early detection of oral squamous cell carcinomas (OSCCs) is urgently needed to improve the prognosis and quality of life (QOL) of patients. Oral leukoplakias (OLs), known as the most common premalignant lesions in the oral cavity, often precede OSCCs. Especially, OLs with dysplasia are known to have a high risk of malignant transformation. Here, we searched for the promoter methylation characteristic...

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PMID: 27255271
DOI: 10.1186/s12885-016-2371-5

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