Article
Control of a tumor suppressor PDCD4: Degradation mechanisms of the protein in hepatocellular carcinoma cells.
Cellular signalling - 1 Mar 2014
Matsuhashi Sachiko, Hamajima Hiroshi, Xia Jinghe, Zhang Hao, Mizuta Toshihiko, Anzai Keizo, Ozaki Iwata
Abstract excerpt
In this study, we demonstrate that EGF inhibits the TGF-β1-induced apoptosis of Huh7 cells. TGF-β1 up-regulates the expression of PDCD4 causing apoptosis, by stimulating the synthesis of PDCD4 mRNA via the Smad signaling pathway. TGF-β1 also inhibits the activation of S6 kinase 1 which phosphorylates the serine 67 residue of PDCD4 and leads to the phosphorylation of serine 71 and serine 76 in the β-TRCP binding...
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