Article
Association between polymorphisms in long non-coding RNA PRNCR1 in 8q24 and risk of colorectal cancer.
Journal of experimental & clinical cancer research : CR - 13 Dec 2013
Li Lijuan, Sun Ruifen, Liang Yundan, Pan Xinmin, Li Zhaohui, Bai Peng, Zeng Xiaofeng, Zhang Dongxian, Zhang Lin, Gao Linbo
Abstract excerpt
BACKGROUND: Genome-wide association studies have identified that genetic variants in 8q24 confer susceptibility to colorectal cancer (CRC). Recently, a novel lncRNA (PRNCR1) that located in the 8q24 was discovered. Single nucleotide polymorphisms (SNPs) in the lncRNAs may influence the process of splicing and stability of mRNA conformation, resulting in the modification of its interacting partners. We...
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