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Article

Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells.

Proceedings of the National Academy of Sciences of the United States of America - 21 Jan 2014

Gilkes Daniele M, Xiang Lisha, Lee Sun Joo, Chaturvedi Pallavi, Hubbi Maimon E, Wirtz Denis, Semenza Gregg L

Abstract excerpt

Overexpression of Rho kinase 1 (ROCK1) and the G protein RhoA is implicated in breast cancer progression, but oncogenic mutations are rare, and the molecular mechanisms that underlie increased ROCK1 and RhoA expression have not been determined. RhoA-bound ROCK1 phosphorylates myosin light chain (...

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Source

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Identifiers

PMID: 24324133
DOI: 10.1073/pnas.1321510111
PMCID: PMC3903228

Genes

ROCK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24324133-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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