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Article

Selective HDAC Inhibition for the Disruption of Latent HIV-1 Infection

19 Aug 2014

Abstract excerpt

Selective histone deacetylase (HDAC) inhibitors have emerged as a potential anti-latency therapy for persistent human immunodeficiency virus type 1 (HIV-1) infection. We utilized a combination of small molecule inhibitors and short hairpin (sh)RNA-mediated gene knockdown strategies to delineate the key HDAC(s) to be targeted for selective induction of latent HIV-1 expression. Individual depletion of HDAC3...

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PMID: 25136952
DOI: 10.1371/journal.pone.0102684

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