Article
Genetic variation in DROSHA 3'UTR regulated by hsa-miR-27b is associated with bladder cancer risk.
PloS one - 1 Jan 2013
Yuan Lin, Chu Haiyan, Wang Meilin, Gu Xiaojian, Shi Danni, Ma Lan, Zhong Dongyan, Du Mulong, Li Pu, Tong Na, Fu Guangbo, Qin Chao, Yin Changjun, Zhang Zhengdong
Abstract excerpt
PURPOSE: miRNAs can regulate the biological processes, including differentiation, proliferation and apoptosis. DICER and DROSHA are two members of RNase III family, playing pivotal roles in the pathway of miRNAs biogenesis. In this study, we hypothesized that genetic variations of the DICER and DROSHA genes were associated with the bladder cancer risk. EXPERIMENTAL DESIGN: We performed a case-control study of 685...
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