Article
Genetic heterogeneity of asthma phenotypes identified by a clustering approach.
The European respiratory journal - 1 Feb 2014
Siroux Valérie, González Juan R, Bouzigon Emmanuelle, Curjuric Ivan, Boudier Anne, Imboden Medea, Anto Josep Maria, Gut Ivo, Jarvis Deborah, Lathrop Mark, Omenaas Ernst Reidar, Pin Isabelle, Wjst Mathias, Demenais Florence, Probst-Hensch Nicole, Kogevinas Manolis, Kauffmann Francine
Abstract excerpt
The aim of the study was to identify genetic variants associated with refined asthma phenotypes enabling multiple features of the disease to be taken into account. Latent class analysis (LCA) was applied in 3001 adults ever having asthma recruited in the frame of three epidemiological surveys (the European Community Respiratory Health Survey (ECRHS), the Swiss Study on Air Pollution and Lung Disease in Adults...
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