Article
Cluster Analysis to Identify Distinct Asthma Phenotypes in the ATLANTIS Cohort.
Allergy - 1 Jan 2026
Kuks Pauline J M, Karp Tatiana, Hartman Jorine E, Kraft Monica, Siddiqui Salman, Fabbri Leonardo M, Beghé Bianca, Rabe Klaus F, Papi Alberto, Brightling Christopher E, Singh Dave, Li Xingnan, Kocks Janwillem W H, Scaffidi-Argentina Ulrica, Kerstjens Huib A M, Heijink Irene H, Pouwels Simon D, Slebos Dirk-Jan, van den Berge Maarten
Abstract excerpt
BACKGROUND: Previous cluster analyses have identified subgroups of asthma. However, only a few studies included parameters of small airways dysfunction (SAD), or gene expression profiles reflecting underlying disease mechanisms. We aimed to identify clinically distinct asthma phenotypes, beyond GINA asthma severity, using available data from the ATLANTIS study which focused on identifying the prevalence of SAD in...
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