Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Vaccinia-related kinase 2 mediates accumulation of polyglutamine aggregates via negative regulation of the chaperonin TRiC.

Molecular and cellular biology - 1 Feb 2014

Kim Sangjune, Park Do-Young, Lee Dohyun, Kim Wanil, Jeong Young-Hun, Lee Juhyun, Chung Sung-Kee, Ha Hyunjung, Choi Bo-Hwa, Kim Kyong-Tai

Abstract excerpt

Misfolding of proteins containing abnormal expansions of polyglutamine (polyQ) repeats is associated with cytotoxicity in several neurodegenerative disorders, including Huntington's disease. Recently, the eukaryotic chaperonin TRiC hetero-oligomeric complex has been shown to play an important role in protecting cells against the accumulation of misfolded polyQ protein aggregates. It is essential to elucidate how...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cells, Cultured
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Huntingtin Protein

Share to Huntington Disease

Share to Nerve Tissue Proteins

Share to Peptides

Share to Protein Folding

Share to Protein Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 24298020
DOI: 10.1128/MCB.00756-13
PMCID: PMC3911496

Genes

VRK2
COP1
RBX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Vaccinia-related kinase 2 mediates accumulation of polyglutamine aggregates via negative regulation of the chaperonin TRiC.PMID 24298020Read ↗

TECPR2 Cooperates with LC3C to Regulate COPII-Dependent ER Export.Semantic proximity Read ↗

Ube2v1 Positively Regulates Protein Aggregation by Modulating Ubiquitin Proteasome System Performance Partially Through K63 Ubiquitination.Semantic proximity Read ↗

Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin-proteasome degradation.Semantic proximity Read ↗

Formation of the VHL-elongin BC tumor suppressor complex is mediated by the chaperonin TRiC.Semantic proximity Read ↗

Chloroplast protein import determines plant proteostasis and retrograde signalingSemantic proximity Read ↗

Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death in polyglutamine diseases.Semantic proximity Read ↗

Vaccinia-related kinase 2 modulates role of dysbindin by regulating protein stability.Semantic proximity Read ↗

Cellular Chaperonin CCTγ Contributes to Rabies Virus Replication during InfectionSemantic proximity Read ↗

Ubiquitination of both Adeno-Associated Virus Type 2 and 5 Capsid Proteins Affects the Transduction Efficiency of Recombinant VectorsSemantic proximity Read ↗

Studies of the role of ubiquitination in the interaction of ubiquilin with the loop and carboxyl terminal regions of presenilin-2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.