Article
Improved accuracy of anticoagulant dose prediction using a pharmacogenetic and artificial neural network-based method.
European journal of clinical pharmacology - 1 Mar 2014
Isma'eel Hussain A, Sakr George E, Habib Robert H, Almedawar Mohamad Musbah, Zgheib Nathalie K, Elhajj Imad H
Abstract excerpt
BACKGROUND: The unpredictability of acenocoumarol dose needed to achieve target blood thinning level remains a challenge. We aimed to apply and compare a pharmacogenetic least-squares model (LSM) and artificial neural network (ANN) models for predictions of acenocoumarol dosing. METHODS: LSM and ANN models were used to analyze previously collected data on 174 participants (mean age: 67.45 SD 13.49 years) on...
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