Article
Beyond Mendel: a call to revisit the genotype-phenotype map through new experimental paradigms.
Genetics - 4 Apr 2026
Tautz Diethard, Pallares Luisa F, Andersson Leif, Barghi Neda, Barton Nick, Bay Rachael, Chan Yingguang Frank, Hancock Angela, Kaiser Tobias S, Koenig Daniel, Kontarakis Zacharias, Liedvogel Miriam, de Meaux Juliette, Nordborg Magnus, Palmer Abraham A, Purugganan Michael, Schlötterer Christian, Schmid Karl, Stainier Didier Y R, Weigel Detlef, Wolf Jochen B W, Ebert Dieter, Gibson Greg
Abstract excerpt
The long-standing notion that genotypes map to phenotypes through simple one gene-one trait relationships continues to shape both research in the life sciences and public understanding, with implications for policy and funding priorities. Yet this paradigm is increasingly recognized as inadequate for explaining continuous phenotypic variation and the complex genetic architectures of the genotype-phenotype map....
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