Article
Is there a paradigm shift in genetics? Lessons from the study of human diseases.
Molecular phylogenetics and evolution - 1 Feb 1996
Weiss K M
Abstract excerpt
The flood of genetic data made possible by recent technological advances has led to a number of important changes in our conceptual model, or working "paradigm," of genetics. Among these changes are recognition that (1) most mutations are unique; (2) there are many alleles at every locus, not just two; (3) these alleles have a hierarchical, or cladistic, history-dependent structure and geographic distribution;...
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