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Article

Effect of genetic variation in a Drosophila model of diabetes-associated misfolded human proinsulin.

Genetics - 1 Feb 2014

He Bin Z, Ludwig Michael Z, Dickerson Desiree A, Barse Levi, Arun Bharath, Vilhjálmsson Bjarni J, Jiang Pengyao, Park Soo-Young, Tamarina Natalia A, Selleck Scott B, Wittkopp Patricia J, Bell Graeme I, Kreitman Martin

Abstract excerpt

The identification and validation of gene-gene interactions is a major challenge in human studies. Here, we explore an approach for studying epistasis in humans using a Drosophila melanogaster model of neonatal diabetes mellitus. Expression of the mutant preproinsulin (hINS(C96Y)) in the eye imag...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24281155
DOI: 10.1534/genetics.113.157800
PMCID: PMC3914626

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24281155-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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