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Article

Genetic complexity in a Drosophila model of diabetes-associated misfolded human proinsulin.

Genetics - 1 Feb 2014

Park Soo-Young, Ludwig Michael Z, Tamarina Natalia A, He Bin Z, Carl Sarah H, Dickerson Desiree A, Barse Levi, Arun Bharath, Williams Calvin L, Miles Cecelia M, Philipson Louis H, Steiner Donald F, Bell Graeme I, Kreitman Martin

Abstract excerpt

Drosophila melanogaster has been widely used as a model of human Mendelian disease, but its value in modeling complex disease has received little attention. Fly models of complex disease would enable high-resolution mapping of disease-modifying loci and the identification of novel targets for the...

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Source

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Identifiers

PMID: 24281154
DOI: 10.1534/genetics.113.157602
PMCID: PMC3914625

Genes

XBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24281154-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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