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Article

Acetate supplementation induces growth arrest of NG2/PDGFRα-positive oligodendroglioma-derived tumor-initiating cells.

PloS one - 1 Jan 2013

Long Patrick M, Tighe Scott W, Driscoll Heather E, Moffett John R, Namboodiri Aryan M A, Viapiano Mariano S, Lawler Sean E, Jaworski Diane M

Abstract excerpt

Cancer is associated with globally hypoacetylated chromatin and considerable attention has recently been focused on epigenetic therapies. N-acetyl-L-aspartate (NAA), the primary storage form of acetate in the brain, and aspartoacylase (ASPA), the enzyme responsible for NAA catalysis to generate acetate and ultimately acetyl-Coenzyme A for histone acetylation, are reduced in oligodendroglioma. The short chain...

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Identifiers

PMID: 24278309
DOI: 10.1371/journal.pone.0080714
PMCID: PMC3835562

Genes

ASPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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