Article
Conserved substitution patterns around nucleosome footprints in eukaryotes and Archaea derive from frequent nucleosome repositioning through evolution.
PLoS computational biology - 1 Jan 2013
Warnecke Tobias, Becker Erin A, Facciotti Marc T, Nislow Corey, Lehner Ben
Abstract excerpt
Nucleosomes, the basic repeat units of eukaryotic chromatin, have been suggested to influence the evolution of eukaryotic genomes, both by altering the propensity of DNA to mutate and by selection acting to maintain or exclude nucleosomes in particular locations. Contrary to the popular idea that nucleosomes are unique to eukaryotes, histone proteins have also been discovered in some archaeal genomes. Archaeal...
Topics
- Archaea
- Eukaryota
- Evolution, Molecular
- Genomics
- Haloferax volcanii
- Humans
- Models, Genetic
- Mutation
- Nucleosomes
- Phylogeny