Article
Purifying selection and birth-and-death evolution in the histone H4 gene family.
Molecular biology and evolution - 1 May 2002
Piontkivska Helen, Rooney Alejandro P, Nei Masatoshi
Abstract excerpt
Histones are small basic proteins encoded by a multigene family and are responsible for the nucleosomal organization of chromatin in eukaryotes. Because of the high degree of protein sequence conservation, it is generally believed that histone genes are subject to concerted evolution. However, purifying selection can also generate a high degree of sequence homogeneity. In this study, we examined the long-term...
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