Article
Genetic variations of immunoregulatory genes associated with Rasmussen syndrome.
Epilepsy research - 1 Dec 2013
Takahashi Yukitoshi, Mogami Yukiko, Mine June, Imai Katsumi, Koide Yasumichi, Matsuda Kazumi, Akasaka Noriyuki, Konishi Takashi, Imamura Atsushi, Inoue Yushi
Abstract excerpt
OBJECTIVE: To elucidate the genetic predisposition of Rasmussen syndrome (RS). METHODS: In 29 Japanese patients, we examined the genome sequences of cytotoxic T-lymphocyte-associated protein 4 (CTLA4), programmed cell-death 1 (PDCD1), and T-bet (TBX21) genes by direct sequencing, and evaluated the significance of SNPs (single nucleotide polymorphism) by comparison with Hap Map data. RESULTS: In all patients, no...
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