Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MLK3 phosphorylation by ERK1/2 is required for oxidative stress-induced invasion of colorectal cancer cells.

Oncogene - 22 Feb 2018

Schroyer A L, Stimes N W, Abi Saab W F, Chadee D N

Abstract excerpt

Mixed lineage kinase 3 (MLK3) functions in migration and/or invasion of several human cancers; however, the role of MLK3 in colorectal cancer (CRC) invasion is unknown. MLK3 is a mitogen-activated protein kinase (MAPK) kinase kinase (MAP3K) which activates MAPK pathways through either kinase-dependent or -independent mechanisms. Human colorectal tumors display increased levels of reactive oxygen species (ROS) or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Neoplasms
Share to MAP Kinase Kinase Kinases
Share to Mitogen-Activated Protein Kinase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitogen-Activated Protein Kinase 3

Share to Mutagenesis, Site-Directed

Share to Neoplasm Invasiveness

Share to Oxidative Stress

Share to Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 29084209
DOI: 10.1038/onc.2017.396
PMCID: PMC5823719

Genes

SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

MLK3 phosphorylation by ERK1/2 is required for oxidative stress-induced invasion of colorectal cancer cells.PMID 29084209Read ↗

Proteomics Identification of ITGB3 as a Key Regulator in Reactive Oxygen Species-induced Migration and Invasion of Colorectal Cancer CellsSemantic proximity Read ↗

MKK3 sustains cell proliferation and survival through p38DELTA MAPK activation in colorectal cancerSemantic proximity Read ↗

Hydrogen peroxide activates focal adhesion kinase and c-Src by a phosphatidylinositol 3 kinase-dependent mechanism and promotes cell migration in Caco-2 cell monolayers.Semantic proximity Read ↗

Melatonin inhibits the Migration of Colon Cancer RKO cells by Down-regulating Myosin Light Chain Kinase Expression through Cross-talk with p38 MAPKSemantic proximity Read ↗

β3 integrin promotes TGF-β1/H2O2/HOCl-mediated induction of metastatic phenotype of hepatocellular carcinoma cells by enhancing TGF-β1 signaling.Semantic proximity Read ↗

Reactive oxygen species in colorectal cancer: The therapeutic impact and its potential roles in tumor progression via perturbation of cellular and physiological dysregulated pathwaysSemantic proximity Read ↗

Reactive oxygen species and colorectal cancer.Semantic proximity Read ↗

ENO3 promotes colorectal cancer progression by enhancing cell glycolysisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.