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Article

Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature

18 Mar 2019

Abstract excerpt

BACKGROUND: Primary mesenchymal stem cells (MSCs) are fraught with aging-related shortfalls. Human-induced pluripotent stem cell (iPSC)-derived MSCs (iMSCs) have been shown to be a useful clinically relevant source of MSCs that circumvent these aging-associated drawbacks. To date, the extent of the retention of aging-hallmarks in iMSCs differentiated from iPSCs derived from elderly donors remains unclear....

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PMID: 30885246
DOI: 10.1186/s13287-019-1209-x

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