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Article

Biomarker-driven patient selection for early clinical trials

22 Mar 2013

Abstract excerpt

PURPOSE OF REVIEW: In this study we describe a new trend in biomarker-driven early drug development using enrichment and prescreening strategies. Technical and logistical obstacles that may hinder progress of this approach will be discussed, along with the ethical and financial concerns. RECENT FINDINGS: Advances in tumor biology and human genetics with the identification of driver events and critical...

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PMID: 23493192
DOI: 10.1097/cco.0b013e32835ff3cb

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