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Targeting autophagy as a therapeutic strategy for identification of liganans from Peristrophe japonica in Parkinson’s disease

17 Feb 2021

Abstract excerpt

PD is characterized by the loss of dopaminergic neurons in substantia nigra, and the loss of dopamine resulting in motor deficit. 1 Its main pathological hallmarks include the genetic mutations of gene such as α-synuclein. 2 Increasing study showed that the dopaminergic neurons in midbrain are sensitive and damaged by the PD toxins. 6-Hydroxydopamine (6-OHDA) is widely used to induce lesion of nigrostriatal...

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PMID: 33594053
DOI: 10.1038/s41392-020-00442-x

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