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Article

Data and implication based comparison of two chronic myeloid leukemia models.

Mathematical biosciences and engineering : MBE - 1 Jan 2000

Everett R A, Zhao Y, Flores K B, Kuang Yang

Abstract excerpt

Chronic myeloid leukemia, a disorder of hematopoietic stem cells, is currently treated using targeted molecular therapy with imatinib. We compare two models that describe the treatment of CML, a multi-scale model (Model 1) and a simple cell competition model (Model 2). Both models describe the competition of leukemic and normal cells, however Model 1 also describes the dynamics of BCR-ABL, the oncogene targeted...

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Source

Identifiers

PMID: 24245631
DOI: 10.3934/mbe.2013.10.1501

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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