Article
Molecular sub-group-specific immunophenotypic changes are associated with outcome in recurrent posterior fossa ependymoma.
Acta neuropathologica - 1 May 2014
Hoffman Lindsey M, Donson Andrew M, Nakachi Ichiro, Griesinger Andrea M, Birks Diane K, Amani Vladimir, Hemenway Molly S, Liu Arthur K, Wang Michael, Hankinson Todd C, Handler Michael H, Foreman Nicholas K
Abstract excerpt
Better understanding of ependymoma (EPN) biology at relapse is needed to improve therapy at this critical event. Convincing data exist defining transcriptionally distinct posterior fossa (PF) sub-groups A and B at diagnosis. The clinical and biological consequence of these sub-groups at recurrence has not yet been defined. Genome and transcriptome microarray profiles and clinical variables of matched primary and...
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