Article
Integrating protein-protein interaction networks with phenotypes reveals signs of interactions.
Nature methods - 1 Jan 2014
Vinayagam Arunachalam, Zirin Jonathan, Roesel Charles, Hu Yanhui, Yilmazel Bahar, Samsonova Anastasia A, Neumüller Ralph A, Mohr Stephanie E, Perrimon Norbert
Abstract excerpt
A major objective of systems biology is to organize molecular interactions as networks and to characterize information flow within networks. We describe a computational framework to integrate protein-protein interaction (PPI) networks and genetic screens to predict the 'signs' of interactions (i.e., activation-inhibition relationships). We constructed a Drosophila melanogaster signed PPI network consisting of...
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