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Article

Prevalence of the apolipoprotein E Arg145Cys dyslipidemia at-risk polymorphism in African-derived populations.

The American journal of cardiology - 15 Jan 2014

Abou Ziki Maen D, Strulovici-Barel Yael, Hackett Neil R, Rodriguez-Flores Juan L, Mezey Jason G, Salit Jacqueline, Radisch Sharon, Hollmann Charleen, Chouchane Lotfi, Malek Joel, Zirie Mahmoud A, Jayyuosi Amin, Gotto Antonio M, Crystal Ronald G

Abstract excerpt

Apolipoprotein E, a protein component of blood lipid particles, plays an important role in lipid transport. Different mutations in the apolipoprotein E gene have been associated with various clinical phenotypes. In an initiated study of Qataris, we observed that 17% of the African-derived genetic subgroup were heterozygotes for a rare Arg145Cys (R145C) variant that functions as a dominant trait with incomplete...

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Identifiers

PMID: 24239320
DOI: 10.1016/j.amjcard.2013.09.021
PMCID: PMC3943837

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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