Article
An 1H-MRS framework predicts the onset of Alzheimer's disease symptoms in PSEN1 mutation carriers.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Sept 2014
Londono Ana C, Castellanos Francisco X, Arbelaez Andres, Ruiz Adriana, Aguirre-Acevedo Daniel C, Richardson Alice M, Easteal Simon, Lidbury Brett A, Arcos-Burgos Mauricio, Lopera Francisco
Abstract excerpt
BACKGROUND: Alzheimer's disease (AD) is the most common cause of dementia; the main risk factors are age and several recently identified genes. A major challenge for AD research is the early detection of subjects at risk. The aim of this study is to develop a predictive model using proton magnetic resonance spectroscopy (1H-MRS), a noninvasive technique that evaluates brain chemistry in vivo, for monitoring the...
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