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Article

Whole-blood global DNA methylation is increased in amyotrophic lateral sclerosis independently of age of onset

13 Nov 2013

Abstract excerpt

ALS is a heterogeneous disease that is not well understood. Epigenetic rearrangements are important in complex disorders including motor neuron diseases. The aim of this study was to determine whether whole-blood DNA methylation (DNA MET %) is a potential modifier of age at onset in ALS. DNA MET % was measured as incorporation of [(3)H]dCTP following HpaII cut in 96 ALS patients and 87 controls, comprising:...

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PMID: 24224837
DOI: 10.3109/21678421.2013.851247

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