Article
MiR-192 directly binds and regulates Dicer1 expression in neuroblastoma.
PloS one - 1 Jan 2013
Feinberg-Gorenshtein Galina, Guedj Avital, Shichrur Keren, Jeison Marta, Luria Drorit, Kodman Yona, Ash Shifra, Feinmesser Meora, Edry Liat, Shomron Noam, Weizman Abraham, Yaniv Isaac, Avigad Smadar
Abstract excerpt
Neuroblastoma (NB) arises from the embryonic neural crest and is the most common extracranial solid tumor in children under 5 years of age. Reduced expression of Dicer1 has recently been shown to be in correlation with poor prognosis in NB patients. This study aimed to investigate the mechanisms that could lead to the down-regulation of Dicer1 in neuroblastoma. We used computational prediction to identify...
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