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Virulence and genotype-associated infectivity of interferon-treated macrophages by porcine reproductive and respiratory syndrome viruses.

Virus research - 22 Jan 2014

García-Nicolás Obdulio, Baumann Arnaud, Vielle Nathalie Jane, Gómez-Laguna Jaime, Quereda Juan José, Pallarés Francisco José, Ramis Guillermo, Carrasco Librado, Summerfield Artur

Abstract excerpt

The polarization into M1 and M2 macrophages (MΦ) is essential to understand MΦ function. Consequently, the aim of this study was to determine the impact of IFN-γ (M1), IL-4 (M2) and IFN-β activation of MΦ on the susceptibility to genotype 1 and 2 porcine reproductive respiratory syndrome (PRRS) virus (PRRSV) strains varying in virulence. To this end, monocyte-derived MΦ were generated by culture during 72h and...

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Identifiers

PMID: 24220223
DOI: 10.1016/j.virusres.2013.08.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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