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Article

Induction of type I interferons by a novel porcine reproductive and respiratory syndrome virus isolate.

Virology - 25 Oct 2012

Nan Yuchen, Wang Rong, Shen Meiyan, Faaberg Kay S, Samal Siba K, Zhang Yan-Jin

Abstract excerpt

Porcine reproductive and respiratory syndrome virus (PRRSV) is known to interfere with the signaling of type I interferons (IFNs). Here we found PRRSV A2MC2 induced type I IFNs in cultured cells. A2MC2 replication in MARC-145 cells resulted in the synthesis of IFN-α2 protein, transcript elevation of the IFN-stimulated genes ISG15 and ISG56, and the proteins of the signal transducer and activator of transcription...

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Source

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Identifiers

PMID: 22704065
DOI: 10.1016/j.virol.2012.05.015
PMCID: PMC7111977

Genes

ISG15
PAM
STAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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