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Modulation of Type I Interferon System by African Swine Fever Virus

9 May 2020

Abstract excerpt

African Swine Fever Virus (ASFV) has tropism for macrophages, which seems to play a crucial role in disease pathogenesis and viral dissemination. Previous studies showed that ASFV developed mechanisms to evade type I interferon (IFN) responses. Hence, we analyzed the ability of ASFV strains of diverse virulence to modulate IFN-β and IFN-α responses. Porcine monocyte-derived macrophages un-activated (moMΦ) or...

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PMID: 32397378
DOI: 10.3390/pathogens9050361

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