Article
Association of OSMR gene polymorphisms with rheumatoid arthritis and systemic lupus erythematosus patients.
Autoimmunity - 1 Feb 2014
Lin Yuan-Zhao, Li Ruei-Nian, Lin Chia-Hui, Ou Tsan-Teng, Wu Cheng-Chin, Tsai Wen-Chan, Liu Hong-Wen, Yen Jeng-Hsien
Abstract excerpt
Cytokines are involved in the pathogenesis of autoimmune diseases. Oncostatin M receptor (OSMR) activates JAK/STAT and MAPK pathways leading to the stimulation of a variety of cytokines and inflammatory substances. Many pro-inflammatory cytokines are involved in the inflammatory process of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). In this study, we carried out experiments to examine the...
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